Isl1^tm1(cre)Tmj
Targeted Allele Detail

Summary

• Symbol: Isl1^tm1(cre)Tmj
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:2447758
• Synonyms: Isl1^cre, Isl1-Cre, Isl1-IRES-Cre, Isl1^tm1(cre)Cos, Isl-Cre, Islet1:Cre
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm1(cre)Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80963
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Isl1^tm1(cre)Tmj expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Isl1 (MGI:101791)

• Mutation details: An IRES-Cre-SV40pA cassette was inserted into the exon encoding the second LIM domain of Isl1. Endogenous regulatory sequences drive Cre expression in motor neurons and dorsal root and cranial sensory ganglia. (J:80963)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Isl1 (mouse) Summary of all recombinase alleles driven by Isl1. Comparative matrix view of recombinase activities Alliance mouse Isl1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

33 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 33 strains or lines available

References

• Original: J:80963 Srinivas S, et al., Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol. 2001;1(1):4
• All: 77 reference(s)