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Targeted Allele Detail
Symbol: Foxo1tm1Whb
Name: forkhead box O1; targeted mutation 1, William H Biggs III
MGI ID: MGI:2447732
Synonyms: Foxo1-, FoxO1+
Gene: Foxo1  Location: Chr3:52268336-52353221 bp, + strand  Genetic Position: Chr3, 23.19 cM
Germline Transmission:  Earliest citation of germline transmission: J:79560
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe endogenous locus was disrupted by a beta-geo cassette inserted immediately downstream of the start codon in exon 1 by homologous recombination. The deleted region included the coding region of exon 1 and approximately 3 kb of intronic sequnence. Transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:79560)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxo1 Mutation:  6 strains or lines available
Original:  J:79560 Nakae J, et al., Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002 Oct;32(2):245-53
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory