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Targeted Allele Detail
Symbol: Del(17Abcg5-Abcg8)1Hobb
Name: deletion, Chr 17, Helen H Hobbs 1; targeted mutation 1, Helen H Hobbs
MGI ID: MGI:2447644
Synonyms: Abcg5/Abcg8tm1Hobb, G5G8-
Gene: Del(17Abcg5-Abcg8)1Hobb  Location: unknown  Genetic Position: Chr17, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:80679
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Del(17Abcg5-Abcg8)1Hobb involves 2 genes/genome features (Abcg5, Abcg8) View all
Mutation detailsBoth the Abcg5 and Abcg8 endogenous loci, which are oriented head to head and separated by approximately 400 bp, were disrupted by the integration of a single targeting construct. A neomycin selection cassette flanked by both loxP and frt sites replaced sequence extending from Abcg5 intron 2 into Abcg8 intron 3. The Walker A consensus sequences that make up a portion of the ATP binding sites in both genes were deleted. Northern and Western blot analyses indicated an absence of normal transcript and protein derived from both loci in homozygous mutant mice. (J:80679)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(17Abcg5-Abcg8)1Hobb Mutation:  1 strain or line available
Original:  J:80679 Yu L, et al., Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16237-42
All:  14 reference(s)

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MGI 6.12
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