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Runx1tm1Tani
Targeted Allele Detail
Nomenclature
Symbol: Runx1tm1Tani
Name: runt related transcription factor 1; targeted mutation 1, Ichiro Taniuchi
MGI ID: MGI:2447630
Synonyms: Runx1F
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80690
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 4 was floxed by insertion of a single upstream loxP site and a downstream floxed neo cassette. The neo cassette was subsequently removed by transient expression of cre recombinase in correctly targeted ES cells, leaving exon 4 flanked by loxP sites. (J:80690)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  25 strains or lines available
References
Original:  J:80690 Taniuchi I, et al., Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development. Cell. 2002 Nov 27;111(5):621-33
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory