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Transgene Detail
Symbol: Tg(IghMyc)22Bri
Name: transgene insertion 22, Ralph L Brinster
MGI ID: MGI:2447604
Synonyms: Emu-c-myc, Emu-cmyc Tg, Emu-myc, E-myc, Eu-Myc, Tg-IghMyc-22Bri
Transgene: Tg(IghMyc)22Bri  Location: unknown  
Pro-B tumor in Pknox1tm1Ngc/Pknox1+ Tg(IghMyc)22Bri/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(IghMyc)22Bri expresses 1 gene
Mutation detailsExpression of the mouse Myc transgene is directed to the B cell lineage by the Igh (E mu) enhancer and Myc promoter. The transgene was originally designated Eμ-Myc. (J:78177)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
13 out of 15 transgenic founders developed lymphomas between 6 and 15 weeks of age. The animals became terminally ill and died or were sacrificed.

Hemizygous mice on a C57BL/6 background display increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male.

In conjuction with Tg(BCL2)22Wehi, transgenic mice on a C57BL/6 background exhibit the production of primitive lymphoid tumors within 5 weeks of birth

Original:  J:78177 Adams JM, et al., The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985 Dec 12-18;318(6046):533-8
All:  178 reference(s)

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