About   Help   FAQ
Transgene Detail
Symbol: Tg(IghMyc)22Bri
Name: transgene insertion 22, Ralph L Brinster
MGI ID: MGI:2447604
Synonyms: Emu-c-myc, Emu-cmyc Tg, Emu-myc, E-myc, Tg-IghMyc-22Bri
Transgene: Tg(IghMyc)22Bri  Location: unknown  
Pro-B tumor in Pknox1tm1Ngc/Pknox1+ Tg(IghMyc)22Bri/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL x SJL)F2
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation details
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
13 out of 15 transgenic founders developed lymphomas between 6 and 15 weeks of age. The animals became terminally ill and died or were sacrificed.

Hemizygous mice on a C57BL/6 background display increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male.

In conjuction with Tg(BCL2)22Wehi, transgenic mice on a C57BL/6 background exhibit the production of primitive lymphoid tumors within 5 weeks of birth

Original:  J:78177 Adams JM, et al., The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985 Dec 12-18;318(6046):533-8
All:  164 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.20
The Jackson Laboratory