Tg(Eno2-BCL2)1Orab
Transgene Detail

Summary

• Symbol: Tg(Eno2-BCL2)1Orab
• Name: transgene insertion 1, Ora Bernard
• MGI ID: MGI:2447602
• Synonyms: NSE-bcl-2
• Transgene: Tg(Eno2-BCL2)1Orab Location: unknown
• Alliance: Tg(Eno2-BCL2)1Orab page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-BCL2)1Orab expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: A human BCL2 gene under regulatory control of Eno2 was used for the transgene. Transgene expression was verified by Western blot analysis. Immunohistochemistry showed that transgene expression was restricted to neurons. The Eno2 promoter was used to target transgene expression to neurons. The Eno2 promoter is active as early as embryonic day E10. (J:26571, J:40682)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Nine transgenic lines were created. Line 122 expressed the highest levels of human BCL2 protein and was used for analysis.

References

• Original: J:26571 Farlie PG, et al., bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4397-401
• All: 6 reference(s)