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Tg(APP)8.9Btla
Transgene Detail
Nomenclature
Symbol: Tg(APP)8.9Btla
Name: transgene insertion 8.9, Bruce Lamb
MGI ID: MGI:2447591
Synonyms: APPYAC, hABetaPP, hAPP-YAC, Py8.9, Tg(APP)C9.24Jgh
Transgene: Tg(APP)8.9Btla  Location: unknown  
Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:80947
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(APP)8.9Btla expresses 1 gene
 
Mutation detailsA 650 kb YAC containing the entire human APP gene and 350 kb of flanking sequence was randomly integerated into ES cells. Southern blot analysis confirmed that construct rearrangement did not occur and that the animals carried a single copy of the intact transgene. Quantitative RT-PCR analysis of transgenic and wild-type mice revealed that the levels of transgenic human alternate transcripts corresponded with those of the endogenous alternative transcripts. The human APP promoter drives expression in the brain, heart, kidney and testes. (J:80947)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:80947 Lamb BT, et al., Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]. Nat Genet. 1993 Sep;5(1):22-30
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory