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Transgene Detail
Symbol: Tg(H2-K-BCL2)1Josd
Name: transgene insertion 1, Jos Domen
MGI ID: MGI:2447580
Synonyms: Bcl-2 Tg, H2K-BCL-2, H2K-BCL-2Tg
Transgene: Tg(H2-K-BCL2)1Josd  Location: unknown  
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(H2-K-BCL2)1Josd expresses 1 gene
Mutation detailsA human BCL2 cDNA under regulatory control of the H2-K promoter was used for the transgene. The H2-K promoter was used to drive transgene expression in hematopoietic stem cells. Northern blot analysis detected strong transgene expression in kidney, spleen, thymus, and lung. Weak expression was observed in the liver. Furthermore, Western blot analysis showed transgene expression in lymph nodes, heart, spleen, thymus, liver, and lungs. (J:80894)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Ten transgenic founders were created. Transgenic founders 1038, 1043, and 1053 were used for analysis. All founders tested exhibit similar patterns of transgene expression.
Original:  J:80894 Domen J, et al., Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood. 1998 Apr 1;91(7):2272-82
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
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