Tg(MMTV-Myc)147-9bLed
Transgene Detail

Summary

• Symbol: Tg(MMTV-Myc)147-9bLed
• Name: transgene insertion 147-9b, Philip Leder
• MGI ID: MGI:2447512
• Synonyms: 147-9b, K strain, MMTV-c-myc, MMTV-cMyc, MMTV-myc, MTV-Sma 147-9b, TG.K
• Transgene: Tg(MMTV-Myc)147-9bLed Location: unknown
• Alliance: Tg(MMTV-Myc)147-9bLed page

Transgene origin

• Strain of Origin: (CD-1 x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MMTV-Myc)147-9bLed expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myc (MGI:97250)

• Mutation details: The transgene contains the mouse mammary tumor virus promoter and the mouse myelocytomatosis oncogene and the endogenous Myc promoters. The MMTV promoter droved transgenic expression in the spleen, testis, lung, brain, salivary gland, and mammary (J:72130) and preputial gland. Expression of the transgene was not detected in thymus, pancreas, kidney, liver, heart, or muscle. Five to ten copies of the transgene were inserted at the site of integration. The founder mouse that gave rise to this strain carried two insertions of the transgene, which were separated by breeding into lines carrying either Tg(MMTV-cmyc)147-9aLed or Tg(MMTV-cmyc)147-9bLed. (J:29013)

Tumor Data

List all tumor models in MMHCdb carrying Tg(MMTV-Myc)147-9bLed

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic line 147-9b is also called "TG.K." Lines 147-9a and 147-6 also carry this construct. The construct was designated "MMTV/c-myc" or "MTV-Sma" or "MTV-Sma myc" or "MMTV-Sma myc" or "TG.K."

References

• Original: J:29013 Stewart TA, et al., Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell. 1984 Oct;38(3):627-37
• All: 9 reference(s)