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Tg(PSEN1)S8-4Dbo
Transgene Detail
Nomenclature
Symbol: Tg(PSEN1)S8-4Dbo
Name: transgene insertion S8-4, David R Borchelt
MGI ID: MGI:2447452
Synonyms: S8-4, Tg(PSEN1)1Dbo, wildtype Hu PS1
Transgene: Tg(PSEN1)S8-4Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  Not Applicable
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene consists of a mouse prion promoter and a cDNA encoding wild-type human presenilin 1. Transgene expression was verified by Northern and Western blot analysis of brain extracts derived from transgenic animals. Lines S8-4, R8-1, H8-4, and B8-1 were generated. (J:34323)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Several transgenic lines were created. S8-4 is one of the highest expressing lines.

References
Original:  J:34323 Thinakaran G, et al., Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 1996 Jul;17(1):181-90
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory