Tg(Ckmm-ADAM12)1Umw
Transgene Detail

Summary

• Symbol: Tg(Ckmm-ADAM12)1Umw
• Name: transgene insertion 1, Ulla M Wewer
• MGI ID: MGI:2447430
• Synonyms: MCK-ADAM12
• Transgene: Tg(Ckmm-ADAM12)1Umw Location: unknown
• Alliance: Tg(Ckmm-ADAM12)1Umw page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckmm-ADAM12)1Umw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ADAM12 (8038)

  Adam12

  (MGI:105378)

• Mutation details: A full length human ADAM12 cDNA was adjoined to the Ckmm (creatine kinase, muscle) promoter fragment. The muscle specfic creatine kinase promoter was shown to drive transgenic expression in adult skeletal muscle by immunohistochemical and Western blot analyses. (J:79904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:79904 Kronqvist P, et al., ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice. Am J Pathol. 2002 Nov;161(5):1535-40
• All: 4 reference(s)