Tg(Ins-MYC/Er)1Gev
Transgene Detail

Summary

• Symbol: Tg(Ins-MYC/Er)1Gev
• Name: transgene insertion 1, Gerard Evan
• MGI ID: MGI:2447354
• Synonyms: Myc⁺, Myc-ER(TAM), MycER^TAM, pIns-c-MycER^TAM, pIns-Myc-ER^TAM
• Transgene: Tg(Ins-MYC/Er)1Gev Location: unknown
• Alliance: Tg(Ins-MYC/Er)1Gev page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: cDNA encoding human c-Myc fused at its C terminus to the hormone binding domain of 4-hydroxytamoxifen (4-OHT)-responsive mutant murine estrogen receptor; expression of the transgene was drived by the rat insulin promoter. (J:76473)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Ins-MYC/Er)1Gev

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76473 Pelengaris S, et al., Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell. 2002 May 3;109(3):321-34
• All: 22 reference(s)