Tg(B2M)1Chmb
Transgene Detail

Summary

• Symbol: Tg(B2M)1Chmb
• Name: transgene insertion 1, Jeffrey W Chamberlain
• MGI ID: MGI:2447342
• Transgene: Tg(B2M)1Chmb Location: unknown
• Alliance: Tg(B2M)1Chmb page

Transgene origin

• Strain of Origin: either: (C57BL/6 and DBA/2) or (C57BL/6 and SJL)

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(B2M)1Chmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  B2M (567)

  B2m	(MGI:88127)

• Mutation details: A 14 kb genomic DNA fragment containing the entire human B2M sequence was used for the transgene. Transgene expression was confirmed by Northern blot analysis. The human transgene is over-expressed 2-fold with an expression pattern similar to that of the endogenous gene. (J:80781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:80781 Chamberlain JW, et al., Tissue-specific and cell surface expression of human major histocompatibility complex class I heavy (HLA-B7) and light (beta 2-microglobulin) chain genes in transgenic mice. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7690-4
• All: 3 reference(s)