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Tg(PSEN1)5Dbo
Transgene Detail
Nomenclature
Symbol: Tg(PSEN1)5Dbo
Name: transgene insertion 5, David R Borchelt
MGI ID: MGI:2447335
Synonyms: APP/PS1, Hu PS1-A246E, PS1A246E, PS1 A246E, PS1-A246E, PS1/A246E, Tg(PSEN1*A246E)5Dbo
Transgene: Tg(PSEN1)5Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
This line was generated from founder number N-5.

Transgenic mice that are also transgenic for Tg(APP695)3Dbo express both human presenilin 1 (A246E variant) and a chimeric amyloid precursor protein (APPSwe) under direction of the mouse prion protein promoter. Elevated levels of the AB1-42(43) peptide are detected in brain homogenates. By nine months of age, histological examination of brain tissue from these mice reveals numerous amyloid deposits resembling those observed in the brains of patients with Alzheimer's disease (AD). The number of amyloid deposits increases dramatically between the ages of 10 and 12 months.

References
Original:  J:80882 Borchelt DR, et al., Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 1996 Nov;17(5):1005-13
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory