About   Help   FAQ
Transgene Detail
Symbol: Tg(PSEN1)5Dbo
Name: transgene insertion 5, David R Borchelt
MGI ID: MGI:2447335
Synonyms: APP/PS1, Hu PS1-A246E, PS1A246E, PS1 A246E, PS1-A246E, PS1/A246E, Tg(PSEN1*A246E)5Dbo
Transgene: Tg(PSEN1)5Dbo  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(PSEN1)5Dbo expresses 1 gene
Mutation detailsThe transgene consists of a mouse prion promoter and a cDNA encoding human presenilin 1 bearing the A246E substitution found in familial Alzheimer's disease (FAD). Transgene expression was verified by Northern and Western blot analysis of brain extracts derived from transgenic animals. (J:80882)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
This line was generated from founder number N-5.

Transgenic mice that are also transgenic for Tg(APP695)3Dbo express both human presenilin 1 (A246E variant) and a chimeric amyloid precursor protein (APPSwe) under direction of the mouse prion protein promoter. Elevated levels of the AB1-42(43) peptide are detected in brain homogenates. By nine months of age, histological examination of brain tissue from these mice reveals numerous amyloid deposits resembling those observed in the brains of patients with Alzheimer's disease (AD). The number of amyloid deposits increases dramatically between the ages of 10 and 12 months.

Original:  J:80882 Borchelt DR, et al., Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 1996 Nov;17(5):1005-13
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory