Tg(PDGFB-PSEN1M146V)3Jhd
Transgene Detail
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Symbol: |
Tg(PDGFB-PSEN1M146V)3Jhd |
Name: |
transgene insertion 3, John Hardy |
MGI ID: |
MGI:2447325 |
Synonyms: |
PS1 M146L line 5.1 |
Transgene: |
Tg(PDGFB-PSEN1M146V)3Jhd Location: unknown
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Alliance: |
Tg(PDGFB-PSEN1M146V)3Jhd page
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Strain of Origin: |
SW x (C57BL/6 x DBA/2)F1
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(PDGFB-PSEN1M146V)3Jhd expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PSEN1 (5663) |
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Transgene codes for a protein with a methionine to valine mutation. |
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Mutation details: A PDGFB promoter fused to a human PSEN1 cDNA, which includes the intron between exons 4 and 5 and carries a methionine to valine substitution at amino acid 146 (M146V), was used for the transgene. The PDGFB promoter was used to drive transgene expression in neurons. Transgene expression was confirmed by Northern and Western blot analysis of brain extracts derived from transgenic animals.
(J:80861)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:80861 Duff K, et al., Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 1996 Oct 24;383(6602):710-3 |
All: |
8 reference(s) |
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