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Cbfbtm2Ppl
Targeted Allele Detail
Nomenclature
Symbol: Cbfbtm2Ppl
Name: core binding factor beta; targeted mutation 2, Pu P Liu
MGI ID: MGI:2447293
Synonyms: CbfbGFP, Cbfb-GFP
Gene: Cbfb  Location: Chr8:105170674-105217989 bp, + strand  Genetic Position: Chr8, 53.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79376
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA knock-in allele was created by fusing a portion of exon 5 (amino acids 1-151) in-frame to a GFP-SV40-hygro cassette. The fusion protein exhibits the same subcellular localization pattern as wild-type and retains the ability to interact with Runx1. (J:79376)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cbfb Mutation:  27 strains or lines available
References
Original:  J:79376 Kundu M, et al., Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11. Blood. 2002 Oct 1;100(7):2449-56
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory