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Targeted Allele Detail
Symbol: Snai2tm1Look
Name: snail family zinc finger 2; targeted mutation 1, A Thomas Look
MGI ID: MGI:2447174
Synonyms: Slug-/-
Gene: Snai2  Location: Chr16:14705859-14709385 bp, + strand  Genetic Position: Chr16, 10.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:80652
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 1.2 kb region of the gene encompassing exon 1 and part of exon 2 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of mouse embryonic fibroblasts derived from homozygous mutant embryos confirmed the absence of gene expression. (J:80652)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snai2 Mutation:  21 strains or lines available
Original:  J:80652 Inoue A, et al., Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell. 2002 Oct;2(4):279-88
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory