Guca2a^tm1Mcoh
Targeted Allele Detail

Summary

• Symbol: Guca2a^tm1Mcoh
• Name: guanylate cyclase activator 2a (guanylin); targeted mutation 1, Mitchell B Cohen
• MGI ID: MGI:2447172
• Gene: Guca2a Location: Chr4:119494929-119496662 bp, + strand Genetic Position: Chr4, 55.47 cM
• Alliance: Guca2a^tm1Mcoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80545
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 4.5 kb fragment (-1886 to +2714, numbering based reference J:80886) encompassing exon 3 and portions of the introns 2 and 3 was left flanked by single loxP sites after the in vitro cre mediated excision of a floxed hprt selection cassette. (J:80545)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Guca2a Mutation: 3 strains or lines available

References

• Original: J:80545 Steinbrecher KA, et al., Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Am J Pathol. 2002 Dec;161(6):2169-78
• All: 1 reference(s)