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Transgene Detail
Symbol: Tg(Prnp)a20Cwe
Name: transgene insertion a20, Charles Weissmann
MGI ID: MGI:2447133
Synonyms: tg20, Tg-20, tga20
Transgene: Tg(Prnp)a20Cwe  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Prnp)a20Cwe expresses 1 gene
Mutation detailsThis transgene encodes a wild-type mouse prion protein. Expression studies demonstrated that this line expresses Prnp transcripts in the brain 6- to 7-fold compared to wild-type. Expression patterns were similar to those of wild-type mice with the notable exception that transcript was not detected in Purkinje cells. This transgenic construct, referred to as 'half genomic,' was designed to omit a large intron in order to facilitate subsequent mutagenesis studies. (J:32214)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:32214 Fischer M, et al., Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J. 1996 Mar 15;15(6):1255-64
All:  62 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory