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Targeted Allele Detail
Symbol: Cd79btm2Mnz
Name: CD79B antigen; targeted mutation 2, Michel C Nussenzweig
MGI ID: MGI:2447117
Gene: Cd79b  Location: Chr11:106311341-106314562 bp, - strand  Genetic Position: Chr11, 68.89 cM
Germline Transmission:  Earliest citation of germline transmission: J:66840
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Nucleotide substitutions
Mutation detailsA targeting vector modified by site-specific mutagenesis to include a nonsense mutation at codon 184 was incorporated at the endogenous locus via homologous recombination. Stopping translation at codon 184 results in the deletion of 45 cytoplasmic amino acids, including those that make up the ITAM. Furthermore, the resultant protein resembles Igh-6 in that it contains only 3 charged cytoplasmic anchor amino acids. An intronic floxed neo cassette was included for selection. (J:66840)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd79b Mutation:  20 strains or lines available
Original:  J:66840 Reichlin A, et al., B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. J Exp Med. 2001 Jan 1;193(1):13-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory