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Tg(Tagln-cre)1Her
Transgene Detail
Summary
Symbol: Tg(Tagln-cre)1Her
Name: transgene insertion 1, Joachim Herz
MGI ID: MGI:2446975
Synonyms: SM, SM22a-Cre, Sm22alphaCre, SM22-Cre, SM22-Cretg, Tag1-Cre, Tgln-Cre
Transgene: Tg(Tagln-cre)1Her  Location: unknown  
Alliance: Tg(Tagln-cre)1Her page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Tagln-cre)1Her expression driven by 1 gene
 
Mutation detailsThe transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells. (J:76460)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tagln (species not specified)
Summary of all recombinase alleles driven by Tagln.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
Tumor Data
List all tumor models in MMHCdb carrying Tg(Tagln-cre)1Her
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
References
Original:  J:76460 Holtwick R, et al., Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A. 2002 May 14;99(10):7142-7
All:  285 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory