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Lmr2C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Lmr2C57BL/6J
Name: leishmaniasis resistance 2; C57BL/6J
MGI ID: MGI:2446907
QTL: Lmr2  Location: Chr9:37032110-50199840 bp  Genetic Position: Chr9, cM position of peak correlated region/allele: 23.41 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers resistance to leishmaniasis compared to BALB/c. This allele confers faster wound healing compared to BALB/cAN. (J:40874, J:102480)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:40874

Analysis of 2 sets of F2 progeny (199 and 271 animals) derived from a BALB/cAnBradleyWEH1 x C57BL/6J cross indicated the presence of quantitative trait loci (QTL) invloved with resistance to Leishmania major infection. BALB/c mice are uniformly susceptible to infection, while C57BL/6 mice are consistently resistant. One QTL, Lmr2, maps to mouse Chromosome 9 between loci D9Mit67 and D9Mit71.

References
Original:  J:40874 Roberts LJ, et al., Resistance to Leishmania major is linked to the H2 region on chromosome 17 and to chromosome 9. J Exp Med. 1997 May 5;185(9):1705-10
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory