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Gct4SJL/Bm
QTL Variant Detail
Nomenclature
QTL variant: Gct4SJL/Bm
Name: granulosa cell tumorigenesis 4; SJL/Bm
MGI ID: MGI:2446888
QTL: Gct4  Location: ChrX:76124336-102062720 bp  Genetic Position: ChrX, Syntenic
Variant
origin
Strain of Specimen:  SJL/Bm
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers susceptibility to granulosa cell turmor formation compared to SWR. (J:49710)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
This allele appears to have a paternal effect. Female animals inheriting this allele from the father exhibit higher tumor incidence compared to females inheriting this allele from the mother.

Gct4 interacts with a closely linked locus named Gct6. SJL-derived alleles at Gct6 enhance the tumor susceptible effect of Gct4SJL.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49710

The authors analyzed three matings for genetic analysis to identify QTLs responsible for tumor susceptibility. 1) F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1;cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1]. 2) The SWR congenic strains [SWR.SJL-X1, SWR.SJL-X2, SWR.SJL-X3, SWR.SJL-X4] containing most of Chromosome X from DXMit55 to DXMit182 and 3)SW x J RI strains. They were ableto identify a SJL derived susceptibility allele on mouse Chromosome X associated with DXMit16. The authors suggest that DXMit16 is not sufficient for tumorigenesis without the SWR susceptibility allele linked to D4Mit232. The authors also identified a parent of origin effect associated with the paternal allele of DXMit16 (chi square = 9.22; P<0.001). Thus females that inherited the SJL allele from the father have higher tumor incidences than those that inherit the allele from their mothers. An interesting candidate gene for Gct4 is the Ar locus which maps less than 1 cM proximal to DXMit16.

References
Original:  J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory