Gct4^SWR/Bm
QTL Variant Detail

Summary

• QTL variant: Gct4^SWR/Bm
• Name: granulosa cell tumorigenesis 4; SWR/Bm
• MGI ID: MGI:2446887
• Synonyms: Gct4^s
• QTL: Gct4 Location: ChrX:76124336-102062720 bp Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: SWR/Bm

Variant description

• Allele Type: QTL

Tumor Data

List all tumor models in MMHCdb carrying Gct4^SWR/Bm

Notes

The gene that controls susceptibility to testosterone treatment is the gene that controls spontaneous tumor formation (J:9301). Three of the SWXJ recombinant inbred strains, along with the SWR/Bm progenitor, will produce granulosa cell (GC) tumors spontaneously, without DHEA treatment. Treatment with testosterone will also induce GC tumors, but only by increasing tumor incidence in those strains that are susceptible to spontaneous tumors (J:4202).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49710

The authors analyzed three matings for genetic analysis to identify QTLs responsible for tumor susceptibility. 1) F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1;cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1]. 2) The SWR congenic strains [SWR.SJL-X1, SWR.SJL-X2, SWR.SJL-X3, SWR.SJL-X4] containing most of Chromosome X from DXMit55 to DXMit182 and 3)SW x J RI strains. They were ableto identify a SJL derived susceptibility allele on mouse Chromosome X associated with DXMit16. The authors suggest that DXMit16 is not sufficient for tumorigenesis without the SWR susceptibility allele linked to D4Mit232. The authors also identified a parent of origin effect associated with the paternal allele of DXMit16 (chi square = 9.22; P<0.001). Thus females that inherited the SJL allele from the father have higher tumor incidences than those that inherit the allele from their mothers. An interesting candidate gene for Gct4 is the Ar locus which maps less than 1 cM proximal to DXMit16.

References

• Original: J:49710 Beamer WG, et al., Multigenic and imprinting control of ovarian granulosa cell tumorigenesis in mice. Cancer Res. 1998 Aug 15;58(16):3694-9
• All: 4 reference(s)