About   Help   FAQ
Slc11a1tm1Mcg
Targeted Allele Detail
Nomenclature
Symbol: Slc11a1tm1Mcg
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; targeted mutation 1, McGill University
MGI ID: MGI:2446573
Synonyms: Nramp1-
Gene: Slc11a1  Location: Chr1:74375195-74386062 bp, + strand  Genetic Position: Chr1, 38.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28278
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 500 nt fragment containing a portion of exon 7 and all of exon 8 was replaced with a neomycin selection cassette inserted by homologous recombination. Whereas Northern blot analyses showed an absence of normal transcript, aberrant transcripts containing neo sequence were detected in homozygous mutant mice. Translation of the mutant transcripts was expected to result in truncated peptides lacking 8 of the 12 endogenous transmembrane domains. (J:28278)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc11a1 Mutation:  13 strains or lines available
References
Original:  J:28278 Vidal S, et al., The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med. 1995 Sep 1;182(3):655-66
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory