Ltb/Tnf^tm1Dvk
Targeted Allele Detail

Summary

• Symbol: Ltb/Tnf^tm1Dvk
• Name: tumor necrosis factor; targeted mutation 1, Dmitry V Kuprash
• MGI ID: MGI:2446563
• Synonyms: (LTBeta/TNF)^T
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Ltb/Tnf^tm1Dvk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58981
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 5.3 kb region, containing exon 3 of the Ltb locus and exons 3 and 4 of the Tnf locus, was left floxed after the integration of a targeting vector containing a loxP-neo cassette in intron 2 of the Ltb locus and two downstream loxP sites the intergenic region between Ltb and Tnf and in intron 2 of the Tnf locus. An additional loxP site located within the Lta locus in the targeting vector was not integrated due to partial homologous recombination. (J:58981)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 46 strains or lines available

References

• Original: J:58981 Kuprash DV, et al., TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J Immunol. 1999 Dec 15;163(12):6575-80
• All: 1 reference(s)