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Transgene Detail
Symbol: Tg(NEFL-APP)#Nalb
Name: transgene insertion, Josephine Nalbantoglu
MGI ID: MGI:2446543
Synonyms: APP(C104)
Transgene: Tg(NEFL-APP)#Nalb  Location: unknown  
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(NEFL-APP)#Nalb expresses 1 gene
Mutation detailsHuman APP sequence encoding amino acids 591 through 695 was adjoined to the human NEFL regulatory sequences as well as the first exon. Northern blot analysis showed expression of the amyloid derived transcripts, approximately 900 nt long, at levels similar to the endogenous App in the brains of transgenic mice. Western blot analysis using an antibody raised against the beta-amyloid peptide showed a pattern of bands that correlates with carboxy terminal fragments identified in human brain. Three lines were established. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:80639)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:80639 Nalbantoglu J, et al., Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature. 1997 May 29;387(6632):500-5
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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