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Targeted Allele Detail
Symbol: Slc6a3tm2Mca
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 2, Marc G Caron
MGI ID: MGI:2446518
Synonyms: DAT-KD
Gene: Slc6a3  Location: Chr13:73536747-73578672 bp, + strand  Genetic Position: Chr13, 40.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:67549
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
Mutation detailsA hypomorphic allele was generated by the insertion of a cassette containing tTA, PGK-neo, and tetO immediately upstream of the start codon. While expression of tTA was not detected, putatively due to an influence of the PGK promoter, Western blot analysis of homozygous mutant mice showed that the presence of the cassette reduced protein levels by approximately 90% in the striatum. (J:67549)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  49 strains or lines available
Original:  J:67549 Zhuang X, et al., Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1982-7
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory