Cbl^tm2Hua
Targeted Allele Detail

Summary

• Symbol: Cbl^tm2Hua
• Name: Casitas B-lineage lymphoma; targeted mutation 2, Hua Gu
• MGI ID: MGI:2446506
• Synonyms: Cbl^flox
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm2Hua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80427
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites and a floxed neo cassette were inserted on either side of an exon by homologous recombination. Transient expression of cre recombinase in correctly targeted cells removed the floxed neo cassette, leaving behind a loxP-flanked exon. (J:80427)

Tumor Data

List all tumor models in MMHCdb carrying Cbl^tm2Hua

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 57 strains or lines available

References

• Original: J:80427 Naramura M, et al., c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat Immunol. 2002 Dec;3(12):1192-9
• All: 11 reference(s)