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Dkc1tm1.1Bsl
Targeted Allele Detail
Nomenclature
Symbol: Dkc1tm1.1Bsl
Name: dyskeratosis congenita 1, dyskerin; targeted mutation 1.1, Monica Bessler
MGI ID: MGI:2446499
Synonyms: DeltaDC1
Gene: Dkc1  Location: ChrX:75095854-75109777 bp, + strand  Genetic Position: ChrX, 38.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80494
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed region of Dkc1tm1Bsl containing the coding regions of exons 12 through 15 and IRES-neo was excised via in vivo cre mediated recombination in the germline. The deleted region encoded 124 amino acids of the carboxy terminal. (J:80494)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dkc1 Mutation:  7 strains or lines available
References
Original:  J:80494 He J, et al., Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice. Oncogene. 2002 Oct 31;21(50):7740-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory