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Targeted Allele Detail
Symbol: Trraptm1Zqw
Name: transformation/transcription domain-associated protein; targeted mutation 1, Zhao-Qi Wang
MGI ID: MGI:2446467
Synonyms: Trrapt
Gene: Trrap  Location: Chr5:144767732-144859778 bp, + strand  Genetic Position: Chr5, 84.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:71950
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe exon encoding the beginning of the protein's kinase-like domain was flanked upstream by a single loxP site and downstream by a loxP-flanked neomycin resistance-thymidine kinase (neor-tk) cassette inserted into the intron corresponding to intron 64 of the orthologous human gene. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. (J:71950)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trrap Mutation:  91 strains or lines available
No mice derived from ES cells bearing the "floxed" allele from which only the neo-tk cassette had been deleted were recovered.
Original:  J:71950 Herceg Z, et al., Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet. 2001 Oct;29(2):206-11
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory