About   Help   FAQ
Trraptm1Zqw
Targeted Allele Detail
Nomenclature
Symbol: Trraptm1Zqw
Name: transformation/transcription domain-associated protein; targeted mutation 1, Zhao-Qi Wang
MGI ID: MGI:2446467
Synonyms: Trrapt
Gene: Trrap  Location: Chr5:144767732-144859778 bp, + strand  Genetic Position: Chr5, 84.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71950
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe exon encoding the beginning of the protein's kinase-like domain was flanked upstream by a single loxP site and downstream by a loxP-flanked neomycin resistance-thymidine kinase (neor-tk) cassette inserted into the intron corresponding to intron 64 of the orthologous human gene. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. (J:71950)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trrap Mutation:  69 strains or lines available
Notes
No mice derived from ES cells bearing the "floxed" allele from which only the neo-tk cassette had been deleted were recovered.
References
Original:  J:71950 Herceg Z, et al., Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Nat Genet. 2001 Oct;29(2):206-11
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory