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Hoxdtm4.1Ddu
Targeted Allele Detail
Nomenclature
Symbol: Hoxdtm4.1Ddu
Name: homeobox D cluster; targeted mutation 4.1, Denis Duboule
MGI ID: MGI:2445975
Synonyms: HoxDRX, L3
Gene: Hoxd  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49264
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele was generated using the same targeting vector used to generate Hoxdtm4Ddu, which contained a floxed neo cassette followed 303 bp downstream by a 261 bp deletion of region X. The floxed neo cassette was deleted in vitro via cre mediated recombination, leaving a single loxP site and the 261 bp deletion in the intergenic region between Hoxd11 and Hoxd12. (J:49264)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd Mutation:  0 strains or lines available
References
Original:  J:49264 Beckers J, et al., Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?. Dev Dyn. 1998 Sep;213(1):1-11
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory