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Igs16tm1Ddu
Targeted Allele Detail
Nomenclature
Symbol: Igs16tm1Ddu
Name: intergenic site 16; targeted mutation 1, Denis Duboule
MGI ID: MGI:2445961
Synonyms: Evx2/Hoxd13tm3Ddu, HoxDRXII-neo
Gene: Igs16  Location: unknown  Genetic Position: Chr2, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80084
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsA 1.2 kb fragment, located between Evx2 and Hoxd13 and containing region 12, was replaced with a floxed neo cassette. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Evx2/Hoxd13tm3.1Ddu. (J:80084)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igs16 Mutation:  0 strains or lines available
References
Original:  J:80084 Kmita M, et al., Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells. Development. 2002 Dec;129(23):5521-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory