F2rl2^tm1Cgh
Targeted Allele Detail

Summary

• Symbol: F2rl2^tm1Cgh
• Name: coagulation factor II thrombin receptor like 2; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:2445957
• Synonyms: PAR3^-, Par3g^-
• Gene: F2rl2 Location: Chr13:95833428-95839276 bp, + strand Genetic Position: Chr13, 50.38 cM
• Alliance: F2rl2^tm1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49283
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exon 2, which encodes the entire protein except for the signal peptide. An absence of transcript was demonstrated by Northern blot analysis of homozygous mutant mice. No protein was detected by flow cytometric analysis of platelets obtained from homozygous mutant mice. (J:49283)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any F2rl2 Mutation: 26 strains or lines available

References

• Original: J:49283 Kahn ML, et al., A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13;394(6694):690-4
• All: 16 reference(s)