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P2ry12tm1Cjf
Targeted Allele Detail
Nomenclature
Symbol: P2ry12tm1Cjf
Name: purinergic receptor P2Y, G-protein coupled 12; targeted mutation 1, Carolyn J Foster
MGI ID: MGI:2445936
Synonyms: P2Y12-, SP1999-
Gene: P2ry12  Location: Chr3:59216272-59262871 bp, - strand  Genetic Position: Chr3, 29.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70017
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe endogenous locus was disrupted by homologous recombination of a neomycin selection cassette. An absence of transcript in homozygous mutant mice was demonstrated by Northern blot analysis of total brain RNA. (J:70017)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P2ry12 Mutation:  19 strains or lines available
References
Original:  J:70017 Foster CJ, et al., Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest. 2001 Jun;107(12):1591-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory