About   Help   FAQ
Targeted Allele Detail
Symbol: Icostm1Mak
Name: inducible T cell co-stimulator; targeted mutation 1, Tak Mak
MGI ID: MGI:2445839
Synonyms: ICOS-
Gene: Icos  Location: Chr1:60977927-61000320 bp, + strand  Genetic Position: Chr1, 30.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:66702
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 2 and all of exons 3 and 4 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the putative Icosl binding site, the transmembrane domain, and a portion of the intracellular domain including the YMFM motif that potentially binds lipid phosphotidylinositol 3 kinase. Flow cytometric analysis indicated an absence of protein on the surface of activated T cells obtained from homozygous mutant mice. (J:66702)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Icos Mutation:  25 strains or lines available
Original:  J:66702 Tafuri A, et al., ICOS is essential for effective T-helper-cell responses. Nature. 2001 Jan 4;409(6816):105-9
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory