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Targeted Allele Detail
Symbol: Rbp4tm1Gott
Name: retinol binding protein 4, plasma; targeted mutation 1, Max E Gottesman
MGI ID: MGI:2445721
Synonyms: RBP-
Gene: Rbp4  Location: Chr19:38116620-38125321 bp, - strand  Genetic Position: Chr19, 32.75 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:57513
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe endogenous locus was disrupted by the insertion of a neomycin cassette that replaced sequence extending from 252 bp upstream of the TATA box through exon 2. While neither normal transcript or protein was detected by Northern or Western blot analyses of homozygous mutant mice, an elongated transcript and a 28 kDa protein were observed. Analysis of labeled retinol in serum fractions and in vivo binding experiments indicated that the mutant protein was present in high molecular weight aggregates and did not function to transport retinol in circulation. (J:57513)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbp4 Mutation:  9 strains or lines available
Original:  J:57513 Quadro L, et al., Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein. EMBO J. 1999 Sep 1;18(17):4633-44
All:  23 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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