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Calcatm1Hku
Targeted Allele Detail
Nomenclature
Symbol: Calcatm1Hku
Name: calcitonin/calcitonin-related polypeptide, alpha; targeted mutation 1, Hiroki Kurihara
MGI ID: MGI:2445489
Synonyms: alphaCGRP-, CGRP-
Gene: Calca  Location: Chr7:114631478-114636357 bp, - strand  Genetic Position: Chr7, 59.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:80225
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe alphaCGRP sequence was disrupted by replacement of exon 5 with a PGK-neo cassette leaving the calcitonin (CT) sequence uninterrupted. RT-PCR analysis confirmed the absence of alphaCGRP expression in mutant mice while CT expression appears unaffected. Immunohistochemical analysis did not detect alphaCGRP protein in the spinal cords of mutant animals, but thyroid gland samples stain positive for CT. (J:80225)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Calca Mutation:  11 strains or lines available
References
Original:  J:80225 Oh-hashi Y, et al., Elevated sympathetic nervous activity in mice deficient in alphaCGRP. Circ Res. 2001 Nov 23;89(11):983-90
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory