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Targeted Allele Detail
Symbol: Gja1tm1.1Kwi
Name: gap junction protein, alpha 1; targeted mutation 1., Klaus Willecke
MGI ID: MGI:2445472
Synonyms: Cx43del
Gene: Gja1  Location: Chr10:56377300-56390419 bp, + strand  Genetic Position: Chr10, 28.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:78662
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region contained within loxP sites flanking exon 2 and the floxed tk-neo cassette were removed by mating Gja1tm1Kwi animals to cre deleter strain TgN(CMV-cre)1Cgn. Resulting progeny retained a single loxP site and lacZ cassette. (J:78662)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  43 strains or lines available
Original:  J:78662 Theis M, et al., Endothelium-specific replacement of the connexin43 coding region by a lacZ reporter gene. Genesis. 2001 Jan;29(1):1-13
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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