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Targeted Allele Detail
Symbol: Suv39h1tm1Jnw
Name: suppressor of variegation 3-9 1; targeted mutation 1, Thomas Jenuwein
MGI ID: MGI:2445449
Gene: Suv39h1  Location: ChrX:8061171-8074760 bp, - strand  Genetic Position: ChrX, 3.64 cM, cytoband A1-A2
Germline Transmission:  Earliest citation of germline transmission: J:72503
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe endogenous locus was disrupted after codon 40 by homologous recombination of a construct containing lacZ followed by RSV-neo. No protein was detected in homozygous mutant mice by Western blot analysis of testis nuclear extracts. Beta-galactosidase activity was reported in mutant mice. (J:72503)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Suv39h1 Mutation:  5 strains or lines available
ES cell line = E14.1 (129P2/OlaHsd) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).
Original:  J:72503 Peters AH, et al., Loss of the suv39h histone methyltransferases impairs Mammalian heterochromatin and genome stability. Cell. 2001 Nov 2;107(3):323-37
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory