Suv39h1^tm1Jnw
Targeted Allele Detail

Summary

• Symbol: Suv39h1^tm1Jnw
• Name: suppressor of variegation 3-9 1; targeted mutation 1, Thomas Jenuwein
• MGI ID: MGI:2445449
• Gene: Suv39h1 Location: ChrX:7927410-7940999 bp, - strand Genetic Position: ChrX, 3.64 cM, cytoband A1-A2
• Alliance: Suv39h1^tm1Jnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72503
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted after codon 40 by homologous recombination of a construct containing lacZ followed by RSV-neo. No protein was detected in homozygous mutant mice by Western blot analysis of testis nuclear extracts. Beta-galactosidase activity was reported in mutant mice. (J:72503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Suv39h1 Mutation: 9 strains or lines available

Notes

ES cell line = E14.1 (129P2/OlaHsd) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺).

References

• Original: J:72503 Peters AH, et al., Loss of the suv39h histone methyltransferases impairs Mammalian heterochromatin and genome stability. Cell. 2001 Nov 2;107(3):323-37
• All: 17 reference(s)