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Transgene Detail
Symbol: Tg(GFAP-SV40T)1Tvd
Name: transgene insertion 1, Terry Van Dyke
MGI ID: MGI:2445446
Synonyms: TgGFAPT121, TgGFAP-T121, Tg(GFAP-T121)1Tvd
Transgene: Tg(GFAP-SV40T)1Tvd  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThe transgene consists of a 2.2 kb fragment of human GFAP promoter, active in central nervous system cells of the astrocyte lineage, and a mutant SV40 T antigen sequence, which contains a deletion for the small t antigen-specific splice signal and a deletion resulting in truncation of the large T antigen at amino acid 121. Transgene expression in central nervous system cells of the astrocyte lineage was observed by immunohistochemical staining of brain sections from transgenic animals. (J:77132)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
10 out of 13 founder animals developed severe brain abnormalities and died by 7-9 days of age. This transgene differs from Tg(GFAP-TAg121)1Tvd, which is a derivative of Tg(GFAP-lacZ-TAg121)92Tvd, and contains a loxP site in place of a Cre deleted lacZ cassette.
Original:  J:77132 Xiao A, et al., Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation. Cancer Cell. 2002 Mar;1(2):157-68
All:  1 reference(s)

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