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Pitx2tm4(cre)Jfm
Targeted Allele Detail
Nomenclature
Symbol: Pitx2tm4(cre)Jfm
Name: paired-like homeodomain transcription factor 2; targeted mutation 4, James F Martin
MGI ID: MGI:2445429
Synonyms: delta abccreneo, Pitx2-Cre, Pitx2creneo, Pitx2 delta abccreneo
Gene: Pitx2  Location: Chr3:129199878-129219591 bp, + strand  Genetic Position: Chr3, 57.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79853
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsExon 5, which encodes a portion of the homeodomain, was disrupted by the insertion of a cassette containing IRES, cre recombinase, lacZ, and neo. In situ hybridization results showed that the expression pattern of cre was similar to that of the endogenous gene. The neo was removed by crossing to Flp-expressing mice. (J:79853, J:87220)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pitx2     Summary of all recombinase alleles driven by Pitx2.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  10 strains or lines available
References
Original:  J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory