Pitx2^tm4(cre)Jfm
Targeted Allele Detail

Summary

• Symbol: Pitx2^tm4(cre)Jfm
• Name: paired-like homeodomain transcription factor 2; targeted mutation 4, James F Martin
• MGI ID: MGI:2445429
• Synonyms: delta abc^creneo, Pitx2-Cre, Pitx2^creneo, Pitx2 delta abc^creneo
• Gene: Pitx2 Location: Chr3:128993527-129013240 bp, + strand Genetic Position: Chr3, 57.84 cM
• Alliance: Pitx2^tm4(cre)Jfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pitx2^tm4(cre)Jfm expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pitx2 (MGI:109340)

• Mutation details: Exon 5, which encodes a portion of the homeodomain, was disrupted by the insertion of a cassette containing IRES, cre recombinase, lacZ, and neo. In situ hybridization results showed that the expression pattern of cre was similar to that of the endogenous gene. The neo was removed by crossing to Flp-expressing mice. (J:79853, J:87220)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pitx2 (mouse) Summary of all recombinase alleles driven by Pitx2. Comparative matrix view of recombinase activities Alliance mouse Pitx2 gene page

Disease models

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pitx2 Mutation: 38 strains or lines available

References

• Original: J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
• All: 29 reference(s)