About   Help   FAQ
Pitx2tm3Jfm
Targeted Allele Detail
Nomenclature
Symbol: Pitx2tm3Jfm
Name: paired-like homeodomain transcription factor 2; targeted mutation 3, James F Martin
MGI ID: MGI:2445425
Synonyms: deltac neo
Gene: Pitx2  Location: Chr3:129199878-129219591 bp, + strand  Genetic Position: Chr3, 57.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79853
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was replaced with a floxed neomycin selection cassette. Mice harboring this allele were crossed with transgenic mice expressing cre recombinase to generate an Pitx2tm3.1Jfm, which encodes isoforms a and b, but not the heart- and lung-specific c isoform. (J:79853)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  17 strains or lines available
References
Original:  J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory