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Targeted Allele Detail
Symbol: Pitx2tm3Jfm
Name: paired-like homeodomain transcription factor 2; targeted mutation 3, James F Martin
MGI ID: MGI:2445425
Synonyms: deltac neo
Gene: Pitx2  Location: Chr3:129199878-129219591 bp, + strand  Genetic Position: Chr3, 57.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:79853
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 4 was replaced with a floxed neomycin selection cassette. Mice harboring this allele were crossed with transgenic mice expressing cre recombinase to generate an Pitx2tm3.1Jfm, which encodes isoforms a and b, but not the heart- and lung-specific c isoform. (J:79853)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  18 strains or lines available
Original:  J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory