About   Help   FAQ
Pitx2tm3Jfm
Targeted Allele Detail
Nomenclature
Symbol: Pitx2tm3Jfm
Name: paired-like homeodomain transcription factor 2; targeted mutation 3, James F Martin
MGI ID: MGI:2445425
Synonyms: deltac neo
Gene: Pitx2  Location: Chr3:129199878-129219591 bp, + strand  Genetic Position: Chr3, 57.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79853
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was replaced with a floxed neomycin selection cassette. Mice harboring this allele were crossed with transgenic mice expressing cre recombinase to generate an Pitx2tm3.1Jfm, which encodes isoforms a and b, but not the heart- and lung-specific c isoform. (J:79853)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  9 strains or lines available
References
Original:  J:79853 Liu C, et al., Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. Development. 2002 Nov;129(21):5081-91
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory