Pmch^tm1Emf
Targeted Allele Detail

Summary

• Symbol: Pmch^tm1Emf
• Name: pro-melanin-concentrating hormone; targeted mutation 1, Eleftheria Maratos-Flier
• MGI ID: MGI:2445313
• Synonyms: MCH^-, MCH-KO
• Gene: Pmch Location: Chr10:87926934-87928236 bp, + strand Genetic Position: Chr10, 43.7 cM, cytoband C2
• Alliance: Pmch^tm1Emf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51659
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a neomycin selection cassette. RT-PCR and in situ hybridization indicated an absence of normal transcript. Protein was undetected in brain tissue obtained from homozygous mutant mice. (J:51659)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pmch^tm1Emf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pmch Mutation: 27 strains or lines available

References

• Original: J:51659 Shimada M, et al., Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998 Dec 17;396(6712):670-4
• All: 12 reference(s)