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Pmchtm1Emf
Targeted Allele Detail
Nomenclature
Symbol: Pmchtm1Emf
Name: pro-melanin-concentrating hormone; targeted mutation 1, Eleftheria Maratos-Flier
MGI ID: MGI:2445313
Synonyms: MCH-, MCH-KO
Gene: Pmch  Location: Chr10:88091072-88092375 bp, + strand  Genetic Position: Chr10, 43.7 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51659
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 3 were replaced with a neomycin selection cassette. RT-PCR and in situ hybridization indicated an absence of normal transcript. Protein was undetected in brain tissue obtained from homozygous mutant mice. (J:51659)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pmch Mutation:  13 strains or lines available
References
Original:  J:51659 Shimada M, et al., Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998 Dec 17;396(6712):670-4
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory