Tbxa2r^tm1Cof
Targeted Allele Detail

Summary

• Symbol: Tbxa2r^tm1Cof
• Name: thromboxane A2 receptor; targeted mutation 1, Thomas M Coffman
• MGI ID: MGI:2445297
• Synonyms: Tp^-, TPKO, tpr^-
• Gene: Tbxa2r Location: Chr10:81164565-81171006 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tbxa2r^tm1Cof page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52125
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a PGK-neo cassette into exon 2 disrupted sequence encoding the third transmembrane domain. Though Northern blot analysis identified several aberrant transcripts in homozygous mutant mice, no normal transcript was detected. Binding assays using a labeled thromboxane agonist indicated an absence of functional receptors in both thymocytes and renal sections obtained from homozygous mutant mice. (J:52125)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbxa2r Mutation: 17 strains or lines available

References

• Original: J:52125 Thomas DW, et al., Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest. 1998 Dec 1;102(11):1994-2001
• All: 20 reference(s)