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Targeted Allele Detail
Symbol: Tbxa2rtm1Cof
Name: thromboxane A2 receptor; targeted mutation 1, Thomas M Coffman
MGI ID: MGI:2445297
Synonyms: Tp-, TPKO, tpr-
Gene: Tbxa2r  Location: Chr10:81328731-81335172 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:52125
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe insertion of a PGK-neo cassette into exon 2 disrupted sequence encoding the third transmembrane domain. Though Northern blot analysis identified several aberrant transcripts in homozygous mutant mice, no normal transcript was detected. Binding assays using a labeled thromboxane agonist indicated an absence of functional receptors in both thymocytes and renal sections obtained from homozygous mutant mice. (J:52125)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbxa2r Mutation:  11 strains or lines available
Original:  J:52125 Thomas DW, et al., Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest. 1998 Dec 1;102(11):1994-2001
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory