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Targeted Allele Detail
Symbol: Grk3tm1Rjl
Name: G protein-coupled receptor kinase 3; targeted mutation 1, Robert J Lefkowitz
MGI ID: MGI:2429934
Synonyms: GRK3 (-)
Gene: Grk3  Location: Chr5:112910478-113015660 bp, - strand  Genetic Position: Chr5, 55.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:43423
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 7 and 8 (encoding part of the protein kinase catalytic domain) were replaced with a PGK-neomycin resistance cassette (in the antisense orientation) by homologous recombination. Included in the deleted region was sequence encoding the ATP binding motif of catalytic subdomain I. While transcript was detected by Northern blot analysis of homozygous mutant mice, the absence of protein was verified by Western blot analysis. (J:43423)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grk3 Mutation:  23 strains or lines available
Original:  J:43423 Peppel K, et al., G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J Biol Chem. 1997 Oct 10;272(41):25425-8
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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