Hmox1^tm1Mlee
Targeted Allele Detail

Summary

• Symbol: Hmox1^tm1Mlee
• Name: heme oxygenase 1; targeted mutation 1, Mu-En Lee
• MGI ID: MGI:2429784
• Synonyms: hmox-1^-, HO-1-
• Gene: Hmox1 Location: Chr8:75820249-75827217 bp, + strand Genetic Position: Chr8, 35.59 cM, cytoband C1
• Alliance: Hmox1^tm1Mlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54684
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced exon 3 of the gene. Northern blots of liver RNA and Western blots of total liver protein from homozygous mutant mice showed no detectable transcript or protein, respectively, for the targeted gene. (J:54684)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmox1 Mutation: 33 strains or lines available

References

• Original: J:54684 Yet SF, et al., Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr;103(8):R23-9
• All: 45 reference(s)