Itgal^tm1Wpfl
Targeted Allele Detail

Summary

• Symbol: Itgal^tm1Wpfl
• Name: integrin alpha L; targeted mutation 1, Wai-Ping Fung-Leung
• MGI ID: MGI:2429755
• Synonyms: LFA-1-
• Gene: Itgal Location: Chr7:126895432-126934310 bp, + strand Genetic Position: Chr7, 69.44 cM
• Alliance: Itgal^tm1Wpfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37160
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exon 6 was disrupted by the insertion of a neomycin selection cassette. Flow cytometry showed that an absence of surface expression on lymphocytes and granulocytes obtained from homozygous mutant mice. (J:37160)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgal Mutation: 74 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or E14 (129P2/OlaHsd).

References

• Original: J:37160 Shier P, et al., Impaired immune responses toward alloantigens and tumor cells but normal thymic selection in mice deficient in the beta2 integrin leukocyte function-associated antigen-1. J Immunol. 1996 Dec 15;157(12):5375-86
• All: 1 reference(s)