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Brca1tm2Mak
Targeted Allele Detail
Nomenclature
Symbol: Brca1tm2Mak
Name: breast cancer 1, early onset; targeted mutation 2, Tak W Mak
MGI ID: MGI:2429692
Synonyms: Brca1fl5-6
Gene: Brca1  Location: Chr11:101488764-101551955 bp, - strand  Genetic Position: Chr11, 65.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63282
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 5 and 6 were left flanked by single loxP sites after a floxed hygromycin selection cassette was removed via in vitro cre mediated recombination. (J:63282)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Brca1 Mutation:  86 strains or lines available
References
Original:  J:63282 Mak TW, et al., Brcal required for T cell lineage development but not TCR loci rearrangement. Nat Immunol. 2000 Jul;1(1):77-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory